For many decades, the amount of mRNA has been faulty correlated with the amount of the corresponding protein. This vision has excluded the posttranscriptional regulation such as stability, localization, alternative splicing and translational control. The latest is a crucial mechanism that provides a quick and adaptive response to stress, growth stimuli or nutrient availability. As a consequence, alterations of translational control has been implicated in various pathologies including infectious diseases, neurodegenerative disorder and cancer.

In addition, it has become increasingly clear that RNA is not simply a messenger molecule directing protein synthesis. RNA has multiple, versatile functions in cells, especially in mammalian gene regulation, through miRNA, lncRNA and gRNA actions for example.

This symposium will present recent finding on cancer-associated aberrant RNAs as well as their implication for cancer development and diagnosis. The meeting will also focus on translational control mechanism with keynote lectures from internationally renowned experts and will highlight issue and perspective for this field in cancer biology.

This symposium gathers researchers and students at the new “Institut Universitaire du Cancer de Toulouse” (IUCT) and is intended for all with an interest in RNA and cancer biology, and especially for those not directly working on…

Symposium organized by Yvan MARTINEAU, Stéphane PYRONNET ,Julie GUILLERMET-GUIBERT

and the Scientific Committee of CRCT CRCT.